Eknath Kole

Cardiac Glycosides
Chemistry of Cardiac Glycosides
Chemistry of Natural Products
DRUG Inspectur Exams
GPAT
GPAT-2019 Syllabus
GPAT-2019- COMMON EXCIPIENTS & THEIR SUGGESTED USE LEVELS IN PHARMACEUTICAL PREPARATION
GPAT-2019- Fat Soluble Vitamins
GPAT-2019- GPAT/NIPER IMP TRICKS-1
GPAT-2019- GPAT/NIPER IMP TRICKS-2

GPAT-2019- GPAT/NIPER IMP TRICKS-3
GPAT-2019- GPAT/NIPER IMP TRICKS-4
GPAT-2019- REFERENCE BOOKS
GPAT-2019- Water Soluble Vitamins
Marine Pharmacognosy
Name reactions – The Basis of Organic Chemistry
NIPER
Organic molecular complexes
Pharmacology GPAT-2019- Cholinergic Antagonists
PHARMACOLOGY GPAT-2019-Adrenergic Agonists
Pharmacy GPAT Study Material and MCQS
Question Paper with Answer

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Eknath Kole

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How To Remember Potassium sparing diuretics

GPAT-2019- Water Soluble Vitamins VITAMIN PHYSIOL. FUNCTIONS Deficiency Toxicity U.S. RDA SOURCES THIAMINE (B 1) Anti-beriberi factor (Oral / IM / SC) § Coenzyme in carbohydrate metabolism (2 C atom metabolism getting rid of pyruvic). § Results from eating white wheat polished rice & alcoholics à Beriberi § GI: Anorexia,  HCl § CNS: Fatigue, Mental Disorders, Periph neuritis, § CV: Card. failure / LVH, TC § Very safe; toxicity not marked. Adults > 0.6 mg Infants > 0.4 mg Uses: Beriberi Periph neuritis in DM Neuralgia Mental Disorders § Beef, liver, pork, fish, eggs. § Whole or enriched grains. § Yeast § Vitamin B1 is thermolabile. RIBOFLAVIN (B 2) The yellow green f...

Drug's Antidotes

Important for Pharma Compitative Examination

Organic molecular complexes

Organic molecular complexes — Organic molecular complexes held together by weak forces of the donor-acceptor type or hydrogen bond — For example, dimethylaniline & 2,4,6-trinitroanisole are two compounds that react in the cold to give a molecular complex — Conversely, these two compounds react at high temperature to form a salt in which the components molecules are held together by primary valence bond — Numerous organic complexes are so weak that they cannot be separated from their solution as specific compounds. they are frequently hard to identify by chemical or physical means — Theses molecular complexes are referred to as charge transfer complexes. — Difference between a charge transfer and donor-acceptor complex is that in the former type, resonance makes the major contribution to complex action, while in the latter, dispersion forces and dipole-dipole interaction contribute more to the stability of the complex. — These complexes are bond together ...

Summary of sexually transmitted diseases (STDs)

Advere Effects of Drug's

Important adverse effects of Drug's for Rapid Revision.

Name reactions – The Basis of Organic Chemistry

Name reactions – The Basis of Organic Chemistry You will find the details of the mechanism in text books or the following web sites: http://www.organic-chemistry.org/frames.htm?http://www.organic-chemistry.org/namedreactions/ or http://www.chemlin.de/chemistry/name_reactions.htm or http://www.tomchemie.de/Reaktionsmechanismen/reaktionsmechanismen.htm Acetoacetic Ester Synthesis Acyloin Condensation Aldol Addition + Aldol Condensation Appel Reaction Arbuzov Reaction = Michaelis-Arbuzov Reaction Arndt-Eistert Synthesis Azo Coupling Baeyer-Villiger Oxidation Balz-Schiemann Reaction = Schiemann Reaction Bamford-Stevens Reaction Barton Decarboxylation Barton-McCombie Reaction (Barton Desoxygenation) Baylis-Hillman Reaction Beckmann Rearrangement Benzilic Acid Rearrangement Benzoin Condensation Bergman Cyclization Birch Reduction Bouveault-Blanc Reduction Buchwald-Hartwig Cross ...

Complexation & Application of complexation in Pharmacy

Pharmacology GPAT-2019- Cholinergic Antagonists

Drug Actions Therapeutic Uses Pharmacokinetics Adverse Effects Other Atropine (antimuscarinic) -bind competitively to muscarinic receptors, blocking the binding of Ach -eye: persistent mydriasis, unresponsiveness to light, cycloplegia -blockage of M1 receptors on presynaptic neurons results in bradycardia (low dose) -higher doses block M2 receptors on SA node, causing modest increase in cardiac rate -blocks the salivary glands, causing xerostomia -affects sweat and lacrimal glands -GIT: antispasmodic to reduce activity of GIT -used to reduce hypermotility states of bladder -used for measurement of refractive errors without interference by the accommodative capacity of eye -Antidote for cholinesterase inhibitor insecticides and mushroom poisoning -Used as an antisecretory agent prior to surgery -general actions last about 4 hours -topical application in eye can la...